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. 2022 Aug 12;14:919143. doi: 10.3389/fnagi.2022.919143

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Copyright © 2022 Chu, Wu, Yan, Chen, Fan, Wu, Tao, Ma, Fu, Guo, Dong, Yang and Ge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Region of interest (ROI) placement diagram. The selected ROIs are shown on the T1 maps. (A) temporal lobe and hippocampus; (B) frontal lobe; (C) parietal lobe; (D) occipital lobe; (E) precuneus; (F) splenium of the corpus callosum and genu of the corpus callosum; (G) posterior limb of the internal capsule and lenticular nucleus; (H) corona radiata; (I) centrum semiovale. The central part of the largest layer and the upper and lower adjacent layers of the structure were selected, and the same sized ROIs were drawn in the symmetrical region of the bilateral lobes, avoiding the interference areas, such as the cerebrospinal fluid and blood vessels.