TABLE 4.
NC (N = 20) | MCI (N = 21) | AD (N = 20) | F | p | ||
MMSE | 28.10 ± 0.79 | 25.10 ± 1.48* | 15.60 ± 3.07*# | 211.247 | <0.001 | |
MoCA | 27.70 ± 0.66 | 21.10 ± 3.08* | 10.35 ± 4.10*# | 172.309 | <0.001 | |
HDSR | 28.60 ± 0.50 | 24.76 ± 1.09* | 12.60 ± 3.63*# | 290.460 | <0.001 | |
CDR | 0.00 ± 0.00 | 0.50 ± 0.00 | 1.50 ± 0.58*# | 104.224 | <0.001 | |
DST | 12.25 ± 0.72 | 11.43 ± 1.75 | 9.60 ± 0.60*# | 27.516 | <0.001 | |
VFT | 37.95 ± 3.40 | 30.71 ± 5.98* | 19.65 ± 7.93*# | 46.331 | <0.001 | |
FAB | 17.70 ± 0.57 | 15.95 ± 2.13* | 9.70 ± 3.21*# | 70.175 | <0.001 | |
TMTA (s) | 58.56 ± 7.64 | 72.93 ± 22.85 | 132.73 ± 42.84*# | 38.806 | <0.001 | |
RAVLT | RAVLT immediate | 38.80 ± 1.70 | 30.52 ± 5.51* | 10.00 ± 3.84*# | 271.120 | <0.001 |
RAVLT short | 10.25 ± 0.97 | 4.90 ± 2.63* | 0.05 ± 0.22*# | 192.932 | <0.001 | |
RAVLT long | 9.00 ± 1.17 | 3.10 ± 2.70* | 0.00 ± 0.00*# | 141.308 | <0.001 | |
RAVLT recognition | 13.60 ± 1.35 | 10.57 ± 2.01* | 0.65 ± 2.00*# | 277.294 | <0.001 | |
NPI-Q | NPI-Q1 | 0.00 ± 0.00 | 1.48 ± 5.27 | 11.65 ± 16.78*# | 7.943 | 0.001 |
NPI-Q2 | 0.00 ± 0.00 | 1.00 ± 3.00 | 7.20 ± 9.69*# | 9.033 | <0.001 | |
HAMA | 1.55 ± 4.84 | 11.29 ± 8.30* | 9.70 ± 7.21* | 11.403 | <0.001 | |
HAMD | 1.30 ± 4.00 | 11.19 ± 10.68* | 13.55 ± 7.57* | 13.385 | <0.001 | |
ADL | 20.00 ± 0.00 | 20.24 ± 0.63 | 31.95 ± 8.34*# | 40.996 | <0.001 |
NC, normal cognition; MCI, mild cognitive impairment; AD, Alzheimer’s disease; MMSE, mini-mental state examination; MoCA, Montreal cognitive assessment scale; HDSR, Hasegawa dementia scale revised; CDR, clinical dementia rating scale; DST, digit span test; VFT, verbal fluency test; FAB, frontal assessment battery; TMTA, trail making test A; RAVLT, Rey auditory verbal learning test (immediate recall/short-term delayed recall/long-term delayed recall/recognition); NPI-Q, neuropsychiatric inventory-questionnaire (NPI-Q1: the score of patient, NPI-Q2: the score of caregiver); HAMA, Hamilton anxiety scale; HAMD, Hamilton depression scale; ADL, activity of daily living scale. *p < 0.05 vs. NC group; #p < 0.05 vs. MCI group.