Table 3.
Summary of the polymeric micelles used for skin delivery described in the literature during the past decade. Reprinted from [139] under a CC BY license.
| Active Compounds | Polymers Used in the Composition of Micellar Carrier | Conclusions | Ref. |
|---|---|---|---|
| Anti-Ageing | |||
| Oleanolic Acid | Poloxamer 407 | Enhancement in the efficacy of wrinkle alleviation treatment | [141] |
| Hyaluronan | Oleyl-hyaluronan Hexyl-hyaluronan |
Drug reached deeper layers in porcine skin | [143] |
| CoQ10 | Oleyl-hyaluronan | Enhancement in skin hydration | [143] |
| Acne Vulgaris | |||
| All-trans Retinoic Acid (Tretinoin) | Poly(ethylene glycol)-conjugated Phosphatidylethanolamine | Higher stability profile with slower drug oxidation | [144] |
| All-trans Retinoic Acid (Tretinoin) | Diblock methoxy-poly(ethylene glycol)-poly(hexyl-substituted lactic acid) | Higher efficiency than marketed formulations | [144] |
| Adapalene | D-α-tocopheryl polyethylene glycol 1000 succinate | Targeted drug delivery capacity Higher efficiency at lower dose than the marketed formulations |
[145] |
| Benzoyl Peroxide | Pluronic® F127 | Targeted drug delivery capacity | [146] |
| Psoriasis | |||
| Tacrolimus | Diblock Methoxy-poly(ethylene glycol)-poly(hexyl-substituted lactic acid) | Enhancement in skin drug deposition | [147] |
| Resveratrol | Pluronic® P123 Pluronic® F127 |
Decrease in the cytokine levels | [148] |
| Silibinin | - | Reduction of psoriasis index area | [149] |
| Fungal Infections | |||
| Clotrimazole Econazole nitrate Fluconazole |
Methoxy-poly(ethylene glycol)-poly(hexyl-substituted lactic acid) | Enhancement in skin drug deposition | [150] |
| Terconazole | Pluronic® P123 Pluronic® F127 Cremophor EL |
Higher permeation Higher skin deposition |
[142] |