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. 2022 Aug 17;12(16):2826. doi: 10.3390/nano12162826

Figure 2.

Figure 2

Superparamagnetic iron oxide NPs being used in liver imaging and lymph node imaging. (A,B): T2-weighted MR image of a liver with a large hepatocellular carcinoma before (A) and after (B) the administration of SPION. The lesion is demarcated with arrows. (C,D): Standard (C) and SPION-based contrast-enhanced (D) MR imaging of liver metastasis in a patient with colorectal cancer. After administration of ferumoxide SPION, a second metastasis becomes visible on T2-weighted MR image. (E,H): Lymph node in left iliac region (arrow), with and without metastatic infiltration. T2-weighted images before (E,G) and 24 h after (F,H) administration of ferumoxtran. Lymph node (arrow) appears bright before injection of UPIO (E,G). One day after injection, a signal loss in the lymph node (arrow) due to high UPIO macrophage uptake can be observed, thus indicating functionality and no metastasis (F). Conversely, in the lower panel, the lymph node (arrow) stays bright, indicating no trafficking of USPIO and thus metastatic colonization (H). Reprinted with permission from Ref. [30]. Copyright 2020 Elsevier.