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. 2022 Aug 16;14(8):1711. doi: 10.3390/pharmaceutics14081711

Figure 1.

Figure 1

Diagram expressing steps in β–sito–Alg/Ch/NPs preparation. Aqueous alginate (1 mg/mL) solution pH lined up to 5.2 (A); Incorporation of β–sito solution to the alginate solution (B); Subsequent addition of CaCl2 solution to the alginate solution (C) via injectable needle measuring volume 0.5 mL/min following uninterrupted stirring, 1000 ± 5 rpm for 30 min, consequently entangling β–sito in a complex structure of calcium–alginate (D); Drop-wise addition of the chitosan solution to the alginate solution (E), a self-assembled β–sito–Alg/Ch/NPs formulation resulted (F).