TABLE 2.
Severe potential drug-drug interactions that were found for at least 3 patients.
| Drug-drug interaction | Stockley’s | Drugs.com | MediQ | Frequency, n (%) |
|---|---|---|---|---|
| Acetylsalicylic acid < = > Enoxaparin | moderate | severe | moderate | 21 (3.3%) |
| Enoxaparin < = > Ibuprofen | moderate | severe | moderate | 16 (2.6%) |
| Baclofen < = > Ibuprofen | severe | — | mild | 15 (2.4%) |
| Ibuprofen < = > Methylprednisolone | severe | moderate | — | 14 (2.2%) |
| Enoxaparin < = > Ramipril | severe | moderate | mild | 13 (2.1%) |
| Citalopram < = > Methylprednisolone | severe | — | moderate | 10 (1.6%) |
| Dipyrone/metamizole < = > Methylprednisolone | severe | — | mild | 9 (1.4%) |
| Methylprednisolone < = > Solifenacin | severe | — | — | 9 (1.4%) |
| Acetaminophen/paracetamol < = > Ibuprofen | severe | — | mild | 7 (1.1%) |
| Citalopram < = > Fingolimod | severe | severe | moderate | 7 (1.1%) |
| Interferon beta-1a < = > Ramipril | severe | moderate | — | 7 (1.1%) |
| Mitoxantrone < = > Ondansetron | severe | — | — | 7 (1.1%) |
| Acetylsalicylic acid < = > Ibuprofen | severe | severe | moderate | 6 (1.0%) |
| Amlodipine < = > Simvastatin | mild | severe | moderate | 6 (1.0%) |
| Citalopram < = > Ibuprofen | severe | moderate | mild | 6 (1.0%) |
| Ibuprofen < = > Teriflunomide | — | severe | — | 6 (1.0%) |
| Acetylsalicylic aci < = > Dipyrone/metamizole | severe | — | moderate | 5 (0.8%) |
| Citalopram < = > Solifenacin | severe | severe | moderate | 5 (0.8%) |
| Methylprednisolone < = > Tizanidine | severe | — | — | 5 (0.8%) |
| Acetylsalicylic acid < = > Duloxetine | severe | moderate | mild | 4 (0.6%) |
| Candesartan < = > Enoxaparin | severe | moderate | mild | 4 (0.6%) |
| Citalopram < = > Fampridine | severe | — | — | 4 (0.6%) |
| Diclofenac < = > Enoxaparin | moderate | severe | moderate | 4 (0.6%) |
| Diclofenac < = > Methylprednisolone | severe | moderate | — | 4 (0.6%) |
| Escitalopram < = > Pantoprazole | severe | — | mild | 4 (0.6%) |
| Ramipril < = > Teriflunomide | — | severe | — | 4 (0.6%) |
| Ramipril < = > Tizanidine | moderate | severe | mild | 4 (0.6%) |
| Acetylsalicylic acid < = > Teriflunomide | — | severe | mild | 3 (0.5%) |
| Acetylsalicylic acid < = > Venlafaxine | severe | moderate | mild | 3 (0.5%) |
| Amlodipine < = > Magnesium | severe | — | — | 3 (0.5%) |
| Baclofen < = > Levodopa | severe | moderate | moderate | 3 (0.5%) |
| Bisoprolol < = > Tamsulosin | severe | — | mild | 3 (0.5%) |
| Ciprofloxacin< = > Methylprednisolone | severe | severe | mild | 3 (0.5%) |
| Citalopram < = > Dronabinol | severe | moderate | mild | 3 (0.5%) |
| Citalopram < = > Mitoxantrone | severe | — | — | 3 (0.5%) |
| Duloxetine < = > Ibuprofen | severe | moderate | mild | 3 (0.5%) |
| Enoxaparin < = > Valsartan | severe | moderate | mild | 3 (0.5%) |
| Escitalopram < = > Fingolimod | severe | severe | moderate | 3 (0.5%) |
| Escitalopram < = > Ibuprofen | severe | moderate | mild | 3 (0.5%) |
| Insulin glargine < = > Ramipril | severe | moderate | mild | 3 (0.5%) |
| Methylprednisolone < = > Teriflunomide | — | severe | — | 3 (0.5%) |
| Mitoxantrone < = > Solifenacin | severe | — | — | 3 (0.5%) |
| Solifenacin < = > Torasemide | severe | — | — | 3 (0.5%) |
The medication schedules of a total of 627 patients with CIS/MS were evaluated using three drug interaction databases. This table lists 43 pDDIs (sorted by frequency) that were classified as severe in at least one of the databases and that were found for n ≥ 3 patients. Please note that the severity levels from Drugs.com (minor, moderate and major) and MediQ (low, average and high) were relabeled here according to those from Stockley’s. Disease-modifying drugs for MS are marked in bold. — = not recorded in the database; CIS, clinically isolated syndrome; MS, multiple sclerosis; pDDI, potential drug-drug interaction.