Table 10.
Different conditions used for the synthesis of [177Lu]Lu-DOTAGA-OncoFAP.
| Radiosynthesis of [177Lu]Lu-DOTAGA-OncoFAP | ||||
|---|---|---|---|---|
| Condition 1 | Condition 2 | Condition 3 | Condition 4 | |
| DOTAGA-OncoFAP (µg) | 13.3 ± 0.25 | 5.1 ± 0.15 | 8.2 ± 0.50 | 5.3 ± 0.15 |
| Reaction volume (mL) | 2.5 | 2.5 | 2.5 | 1.5 |
| Initial activity (MBq) | 592 ± 9 | 870 ± 6 | 1047 ± 19 | 573 ± 6 |
| Product activity (MBq) | 577 ± 8 | 307 ± 5 | 670 ± 25 | 533 ± 6 |
| RCY % | 97.4 ± 0.4 | 35.3 ± 1.9 | 54.8 ± 1.3 | 92.9 ± 0.75 |
| Gentisic acid (mg) | 0 | 20 | 20 | 20 |
| Final molar activity (GBq/µmol) | 43 ± 2 | 60 ± 5 | 83 ± 3 | 100 ± 3 |
| RCP (%) | > 99.8 | >99.8 | > 99.8 | > 99.8 |