Table 2.
A summary of the cytotoxic effects of BN, 28-TPP⊕ BN (7), and 3,28-bisTPP⊕ BN (9) on the HCT 116 and MCF-7 cancer cell lines and NHDF.
| No. | R | n | Activity IC50, µM a,b | ||
|---|---|---|---|---|---|
| HCT 116 | MCF-7 | NHDF | |||
| BN | − | − | neg | neg | neg |
| 7a | H | 3 | 5.56 ± 0.28 | 13.71± 0.54 | 9.68 ± 0.27 |
| 7b | H | 4 | 5.77 ± 0.27 | 14.35 ± 0.38 | 10.71 ± 0.25 |
| 7c | H | 5 | 6.48 ± 0.04 | 15.52 ± 0.92 | 11.29 ± 0.53 |
| 7f | Me | 5 | 12.71 ± 0.89 | 50.47 ± 3.92 | 10.03 ± 0.48 |
| 9a | H | 3 | 6.32 ± 0.27 | 31.30 ± 3.02 | 5.91 ± 0.33 |
| 9b | H | 4 | 7.97 ± 0.51 | 23.60 ± 0.33 | 8.02 ± 0.35 |
| 9c | H | 5 | 18.99 ± 0.51 | 53.30 ± 5.41 | 10.60 ± 0.34 |
a Cytotoxicity was evaluated using the CCK-8 assay; b Incubation time 24 h; Data are presented as the mean ± standard deviation (n = 3); neg: no activity in the concentration range used.