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. 2022 Aug 22;12(8):772. doi: 10.3390/metabo12080772

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Changes in sTYR/sPHE & uTYR₂₄/uPHE₂₄, and sHPLA/sTYR & uHPLA₂₄/uTYR₂₄ in the nitisinone group of the SONIA 2. (p-values indicated for comparison between keratopathy and no-keratopathy sampling points where statistical significance was achieved; keratopathy sampling points n = 35; no-keratopathy sampling points n = 272 (data shown as boxplots with median) (statistical significance p expressed * < 0.05, ** < 0.01 and *** < 0.001, respectively).