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. 2022 Aug 16;14(8):1705. doi: 10.3390/pharmaceutics14081705

Figure 2.

Figure 2

Gut microbiota diversity in pediatric patients with hematological malignancies receiving lactoferrin or placebo during induction chemotherapy. (A) Boxplots showing the distribution of alpha diversity, estimated with Faith’s phylogenetic diversity (Faith’s PD) and the number of observed ASVs, before (PRE) and after (POST) placebo (PL) or lactoferrin (LF) supplementation during induction chemotherapy (Wilcoxon test, * for p ≤ 0.05). (B) PCoA based on Bray–Curtis dissimilarities between the gut microbiota profiles of study groups. Ellipses include 95% confidence area based on the standard error of the weighted average of sample coordinates. A significant segregation among groups was found (permutation test with pseudo-F ratio, p = 0.005).