Table 3.
List of anticancer drugs, polymers, and cell lines used in drug-delivery systems for the treatment of stomach cancer with their advantages.
| Drug + System | Polymer Used | Cell Line | Application | References |
|---|---|---|---|---|
| Hydrogels | ||||
| Doxorubicin-loaded single wall nanotube thermo-sensitive hydrogel for gastric cancer chemo-photothermal therapy |
NA | BGC-823 cell line | Efficacy and lesser toxicity | [163] |
| Intraperitoneal administration of cisplatin via an in-situ cross-linkable hyaluronic acid-based hydrogel for peritoneal dissemination of gastric cancer | NA | MKN45P, a human gastric cancer cell line | Sustained drug delivery | [164] |
| Microbubble | ||||
| Docetaxel-loaded lipid microbubble (DLLD) in combination with ultrasound-triggered microbubble destruction (UTMD) on the growth of a gastric cancer cell line |
JC-1 | BGC-823 | More efficient in inhibiting cell proliferation and inducing cell apoptosis in the gastric cancer cell line |
[169] |
| Ultrasound Microbubbles Mediated Sonosensitizer and Antibody Co-delivery on HER2- Positive Gastric Cancer |
NA | HER2-positive gastric cancer NCI-N87 cells |
Significant tumor lethal effect in vitro and distinctly inhibited tumor growth in vivo |
[172] |
| Microparticles | ||||
| 5-fluorouracil-loaded microparticles as biodegradable anticancer drug carriers |
biodegradable poly ((±)-lactide-co-glycolide) (PLAGA) |
NA | Sustained drug delivery | [173] |
| Drug-loaded microparticles for treatment of peritoneal cancer |
PLGA or poly (lacticco-glycolic acid) copolymer |
NA | Less toxic and more effective against several IP metastatic tumors |
[174] |
| Oral drug delivery | ||||
| 5-fluorouracil-loaded floating gastroretentive hollow microsphere | polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) as drug controlled- release polymer blends. | MCF-7 breast cancer cells to induce tumor in mice | 5-FU hollow microspheres exhibited excellent floating and sustained release characteristics. | [175] |
| Re-assembled casein micelles for oral delivery of chemotherapeutic combinations to overcome multidrug resistance in gastric cancer | NA | Human MDR gastric carcinoma cell line | Casein-based oral delivery systems provide a robust natural platform enabling a spectrum of development possibilities for gastric-activated release of synergistic drug combinations Developed oral drug delivery system showed good floating ability and it retained in GIT for a prolonged period of time. |
[176] |
| Site Specific Hollow Floating Microspheres Bearing 5-Fu |
Eudragit S-100 | NA | system showed good floating ability and it retained in GIT for a prolonged period of time. |
[177] |