Table 1.
Demographic Data
| Parameter | Healthy volunteers (N = 10) | Patients with asthma (N = 9) |
|---|---|---|
| Age, years | 39.1 ± 7.4 (28 to 49) | 42.0 ± 6.2 (32 to 48) |
| Body mass index, kg/m2 | 25.2 ± 3.6 (21.4 to 31.0) | 27.7 ± 2.7 (22.5 to 30.1) |
| Race | ||
| Caucasian | 10 (100) | 8 (88.9) |
| Other | 0 (0) | 1 (11.1) |
| Gender | ||
| Male | 6 (60.0) | 6 (66.7) |
| Female | 4 (40.0) | 3 (33.3) |
| FEV1a | ||
| Absolute, L | 3.84 ± 0.96 (2.72 to 5.46) | 2.51 ± 0.45 (1.50 to 3.06) |
| % predicted | 104.8 ± 9.4 (89 to 120) | 70.9 ± 10.7 (54 to 88) |
| FEV1 reversibility, %b | — | 17.4 ± 3.9 (13 to 24) |
| FVC, La | 4.93 ± 1.29 (3.33 to 7.64) | 4.18 ± 1.06 (2.58 to 6.19) |
| FEV1/FVC ratioa | 0.784 ± 0.086 (0.67 to 0.97) | 0.616 ± 0.097 (0.40 to 0.74) |
| FEF25, L/seca | 7.27 ± 2.15 (4.53 to 10.45) | 3.32 ± 0.91 (1.96 to 4.73) |
| FEF50, L/seca | 4.18 ± 1.39 (2.41 to 7.07) | 1.80 ± 0.55 (0.92 to 2.38) |
| FEF75, L/seca | 1.56 ± 0.89 (0.66 to 3.77) | 0.54 ± 0.17 (0.19 to 0.69) |
Data are mean ± SD (range) or number (%).
a
Assessed at predose during the treatment period.
b
Assessed only in patients with asthma, with data either from patient records or assessed at screening.
FEF, forced expiratory flow; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; SD, standard deviation.