Table 2.
Types of interactions that occurred between the docked 18-mer hCoV E peptides and the PDZ domain of the PALS1 protein. The PALS1 PDZ domain residues to which the docked hCoV E peptides bound are shown at the top (second row) along with the corresponding PBM residue(s) of each docked hCoV E peptide. Residues are grouped according to the type of interaction that forms between them.
| HCoVs | Hydrophobic | Hydrogen | Ionic | π-Stacking | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P266 | L267 | T270 | V271 | R272 | V284 | V314 | F318 | L321 | P266 | L267 | G268 | A269 | T270 | V271 | R272 | S281 | N315 | R272 | E274 | R282 | F318 | |
| 7NTK (8-mer) | none | none | L74 | V75 | V70 | L74 | L73 P71 |
L73 V75 |
V75 | none | V75 | V75 | V75 (×2) | none | L73 (×2) D72 |
none | D72 | none | D72 | none | none | none |
| SARS-CoV-1 | E69 (×2) | none | L74 | none | none | none | L75 | V76 | none | S68 | E69 | E69 | E69 | none | L75 | none | none | none | none | none | D73 | none |
| SARS-CoV-2 | none | none | L74 | V75 | none | none | L73 | L73 V75 |
V75 | none | V75 | V75 | V75 (×2) | D72 | L73 (×2) | none | D72 | none | D72 | R61 | none | none |
| MERS-CoV | V82 | none | none | none | none | none | none | V82 | none | none | V82 | V82 | V82 | none | E80 | P78 | none | none | none | none | none | W81 |
| HCoV-229E | F77 | F77 (×2) | V74 | none | none | none | Y61 (×2) | F77 (×2) | F77 | none | F77 | F77 | F77 | none | Y61 | none | none | I60 Y61 Q62 |
none | none | none | Y61 |
| HCoV-NL63 | none | none | none | none | none | none | none | E73 V74 V77 |
V77 | none | N76 | N76 | N76 | none | V77 | none | none | none | none | none | none | Y61 |