Table A3.

Disease progression rate: $\theta$.

Parameters	Description	Value: Years	Source
$1/{\theta }_1^I$	course of wild strain carriers in stage 1	4	[14]
$1/{\theta }_2^I$	course of wild strain carriers in stage 2	6	[14]
$1/{\theta }_3^I$	course of wild strain carriers in stage 3	2	[14]
$1/{\theta }_1^R$	course of drug-resistant carriers in stage 1	4	[14,39,40]
$1/{\theta }_2^R$	course of drug-resistant carriers in stage 2	6	[14,39,40]
$1/{\theta }_3^R$	course of drug-resistant carriers in stage 3	2	[14,39,40]