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Effect of pyc gene amplification on clavulanic acid and cephamycin biosynthesis. Clavulanic acid (A and B) and cephamycin C (C and D) biosynthesis by S. clavuligerus [pULVK99] (○) and S. clavuligerus[pVKBE2.1] (●) in GSPG medium (A and C) or SA medium (B and D). SD are given as discontinuous bars.
