Table 1.

Experimental data reported in the literature for the solubility of anticancer drugs in supercritical CO₂.

Anticancer Drug	Pressure	Temperature	CO2 Density	Drug Solubility	No. of Data	Ref.
	bar	°C	kg/m3	Mole Fraction
Sunitinib malate	120–270	35–65	388–914	5.00 × 10−6–8.56 × 10−5	24	[23]
Busulfan	120–400	35–65	383–971	3.27 × 10−5–8.65 × 10−4	32	[24]
Tamsulosin	120–270	35–65	384–914	1.80 × 10−7–1.01 × 10−5	24	[28]
Azathioprine	120–270	35–65	388–914	2.70 × 10−6–1.83 × 10−5	24	[42]
Paclitaxel	100–275	35–55	654–915	1.20 × 10−6–6.20 × 10−6	21	[43]
5-Fluorouracil	125–250	35–55	541–901	3.80 × 10−6–1.46 × 10−5	18	[43]
Thymidine	100–300	35–55	325–928	1.20 × 10−6–8.00 × 10−6	25	[43]
Capecitabine	152–354	35–75	477–955	2.70 × 10−6–1.59 × 10−4	35	[44]
Decitabine	120–400	35–65	383–971	2.84 × 10−5–1.07 × 10−3	32	[45]
Letrozole	120–360	45–75	319–922	1.60 × 10−6–8.51 × 10−5	20	[46]
Sorafenib tosylate	120–270	35–65	388–914	6.80 × 10−7–1.26 × 10−5	24	[47]
Tamoxifen	120–400	35–65	383–971	1.88 × 10−5–9.89 × 10−4	32	[48]