Table 3.
Antibody Isotype | Group | Gilt ID | D42 | D44 | D46 | D49 | D52 | D56 |
---|---|---|---|---|---|---|---|---|
DPC 0 | DPC 2 | DPC 4 | DPC 7 | DPC 10 | DPC 14 | |||
IgG | T01 V/C | 5003 | 0.7903 | 0.5831 | X | 0.0166 | 0.8213 | 1.1731 |
5026 | 0.0346 | 0.9321 | 1.1440 | 0.6856 | 0.6884 | 0.7091 | ||
5046 | 0.0596 | 0.0568 | 0.0305 | 0.8089 | 1.5623 | 1.1413 | ||
6174 | 0.0014 | 0.0055 | 0.2008 | 0.4474 | 3.2729 | 3.6745 | ||
Average | 0.2215 a | 0.3944 a | 0.4584 a | 0.4896 a | 1.5862 a | 1.6745 a | ||
T02 N/C | 5043 | −0.0194 | 0.0097 | 0.0222 | 0.0443 | 0.4437 | 0.6971 | |
5048 | 0.0055 | 0.0180 | −0.0069 | 0.1773 | 2.2995 | 2.8063 | ||
6173 | −0.0235 | 0.0097 | 0.0360 | 0.1316 | 0.8698 | 1.1515 | ||
5044 | 0.0235 | 0.0014 | 0.0222 | 0.1510 | X | X | ||
Average | −0.0035 a | 0.0097 a | 0.0184 a | 0.1261 a | 1.2043 a | 1.5516 a | ||
T03 N/N | 6175 | 0.0402 | 0.0000 | 0.0499 | 0.0360 | 0.0147 | −0.0065 | |
5042 | 0.0055 | −0.0028 | 0.0568 | 0.0817 | 0.0147 | 0.0374 | ||
Average | 0.0229 a | −0.0014 a | 0.0534 a | 0.0589 a | 0.0147 a | 0.0155 a | ||
IgA | T01 V/C | 5003 | 0.4527 | 0.3953 | X | 0.0721 | 0.1840 | 0.7342 |
5026 | 0.1324 | 0.5735 | 0.6573 | 0.6446 | 0.8345 | 1.1091 | ||
5046 | 0.1110 | 0.4197 | 0.2425 | 0.3359 | 0.8617 | 0.8111 | ||
6174 | 0.0039 | 0.0662 | 0.1821 | 0.1071 | 0.1918 | 0.5034 | ||
Average | 0.1750 a | 0.3637 a | 0.3606 a | 0.2899 a | 0.5180 a | 0.7895 a | ||
T02 N/C | 5043 | −0.0068 | 0.0302 | 0.0876 | 0.0380 | 0.1255 | 0.4649 | |
5048 | −0.0049 | 0.0292 | 0.0263 | 0.1130 | 0.3385 | 0.8157 | ||
6173 | 0.0010 | 0.1188 | 0.1402 | 0.3359 | 0.2592 | 0.6852 | ||
5044 | 0.0156 | 0.0146 | 0.0769 | 0.0808 | X | X | ||
Average | 0.0012 a | 0.0482 b | 0.0828 a | 0.1419 a | 0.2411 a | 0.6553 a | ||
T03 N/N | 6175 | 0.0516 | 0.0166 | 0.0331 | 0.0380 | 0.0148 | 0.0033 | |
5042 | 0.0380 | 0.0282 | 0.1061 | 0.0935 | 0.0618 | 0.0493 | ||
Average | 0.0448 a | 0.0224 b | 0.0696 a | 0.0658 a | 0.0383 a | 0.0263 b |
Note: V/C: vaccination/challenge; N/C: non-vaccination/challenge; N/N: non-vaccination/non-challenge. DP1V: day post 1st vaccination; DP2V: day post 2nd vaccination; DPC: day post challenge; D0-D58: day of study. X: milk samples not available. Different letters (a and b) indicate statistically significant difference of IgG between groups and IgA between groups at each time point. The positive cutoff for colostrum IgG and IgA was an S/P ratio equal or greater than 0.6, as indicated in red.