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. 2022 Aug 12;15:911476. doi: 10.3389/fnmol.2022.911476

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Copyright © 2022 Liang, Chen, Yang, Yang, Yu, Yang, Wang, Wang, Sun and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Secondary neuroinflammation in the spinal dorsal horn 7 days after ITS or ITC. (A) Representative immunofluorescent photomicrographs showing the expression of Iba-1, GFAP, SDF1, and CXCR4 at the spinal dorsal horn contralateral to ITS or ITC. (B) Quantification of the mean immunofluorescent intensity of Iba-1, GFAP, SDF1, and CXCR4-labeled cellular profiles. ***p < 0.001 ITC vs. ITS, n = 3 rats/group. (C) Representative immunofluorescent photomicrographs showing co-localization of CXCR4 with NeuN, Iba-1, and GFAP-labeled cellular profiles at the spinal dorsal horn contralateral to ITC by orthogonal viewing method. (D) The percentage of CXCR4 in NeuN, Iba-1, and GFAP-labeled cellular profiles. (E) Western blot assay of Iba-1, GFAP, SDF1, and CXCR4 in bilateral dorsal spinal cord 7 days after ITS or ITC. (F) Quantitative analysis of the Western blot results for Iba-1, GFAP, SDF1, and CXCR4 in bilateral dorsal cord following 7 days after ITS or ITC. *p < 0.05, **p < 0.01, ITC vs. ITS, n = 5 rats/group.