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. 2022 Aug 12;15:911476. doi: 10.3389/fnmol.2022.911476

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Copyright © 2022 Liang, Chen, Yang, Yang, Yu, Yang, Wang, Wang, Sun and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evidence for neuronal hyperexcitability or sensitization in spared spinal dorsal horn neurons 7 days after ITS or ITC. MEA recording and analysis of spontaneous type (A) and non-spontaneous type (B) of the three classes of spinal dorsal horn units following ITS and ITC. (C) Probability of frequency distribution of spike responses in LTM, WDR, and NS units to brush, pressure, and pinch stimuli in the spared non-spontaneous type following ITS or ITC. The frequency of spike responses of all three classes of dorsal horn neurons is stimulus intensity-dependent, and ITC group shows more high-frequency spike discharges than ITS group when stimulated by high-intensity mechanical stimuli (pressure and pinch) to both WDR and NS as well as LTM.