Table 5.

Target prediction of crude myrrh resin using Swiss Target and SEA Search.

Compound Number (Name)	SEA Search			Swiss Target
	Predicted Targets	p Value	MaxTC	Predicted Targets	Probability
1 (4,5-Dihydrofuranodienone)	Glucocorticoid receptor Androgen receptor	Inactive Inactive	Inactive Inactive	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen receptor DNA topoisomerase I	NA NA NA 0.098 NA
2 (Furanodienone)	Glucocorticoid receptor Androgen receptor	Inactive Inactive	Inactive Inactive	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen receptor DNA topoisomerase I	0.049 NA 0.049 NA NA
3 (Mansumbinone)	Glucocorticoid receptor Androgen Receptor	Inactive Inactive	Inactive Inactive	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen Receptor DNA topoisomerase I	NA 0.102 NA 0.102 NA
4 (Campestan-3b-ol)	Glucocorticoid receptor Androgen receptor	Inactive Inactive	Inactive Inactive	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen receptor DNA topoisomerase I	NA NA NA NA NA
5 (Cembrene-A)	Glucocorticoid receptor Androgen receptor	Inactive 4.441 × 10−16	Inactive 0.53	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen receptor DNA topoisomerase I	NA NA NA 0.631 NA
6 (Pregnadienes)	Glucocorticoid receptor Androgen receptor	1.121 × 10−12 1.121 × 10−12	1.00 1.00	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen receptor DNA topoisomerase I	NA 1.0 NA 1.0 NA
7 (Z,4Z-Furanodien-6-one)	Glucocorticoid receptor Androgen receptor	Inactive Inactive	Inactive Inactive	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen receptor DNA topoisomerase I	0.049 NA 0.049 NA NA
8 (Guggulsterols)	Glucocorticoid receptor Androgen receptor	1.868 × 10−23 1.218 × 10−19	0.40 0.53	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen Receptor DNA topoisomerase I	0.119 0.473 NA 0.376 NA
9 (3,4-Seco-mansumbinoic acid)	Glucocorticoid receptor Androgen Receptor	Inactive Inactive	Inactive Inactive	Cyclooxygenase-2 Glucocorticoid receptor Beta amyloid A4 protein Androgen receptor DNA topoisomerase I	0.105 0.105 NA 0.113 0.105

NA: not applicable.