Table 8.
Toxicity profiles of myrrh bioactive compounds using ProTox-II online tool.
| Compound Number (Name) | Oral Toxicity of Compounds | Prediction of Active Organ Toxicity/Toxicity Endpoints | Probability | |
|---|---|---|---|---|
| Predicted LD50 (mg/kg) | Predicted Toxicity Class | |||
| 1 (4,5-Dihydrofuranodienone) |
590 | 4 | Hepatotoxicity | 0.61 (Inactive) |
| Immunotoxicity | 0.73 (Inactive) |
|||
| Carcinogenicity | 0.52 (Inactive) |
|||
| Mutagenicity | 0.65 (Inactive) |
|||
| 2 (Furanodienone) |
116 | 3 | Hepatotoxicity | 0.71 (Inactive) |
| Immunotoxicity | 0.96 (Inactive) |
|||
| Carcinogenicity | 0.58 (Inactive) |
|||
| Mutagenicity | 0.84 (Inactive) |
|||
| 3 (Mansumbinone) |
15,000 | 6 | Hepatotoxicity | 0.70 (Inactive) |
| Immunotoxicity | 0.73 (Inactive) |
|||
| Carcinogenicity | 0.57 (Inactive) |
|||
| Mutagenicity | 0.97 (Inactive) |
|||
| 4 (Campestan-3b-ol) |
4400 | 5 | Hepatotoxicity | 0.77 (Inactive) |
| Immunotoxicity | 0.93 (Inactive) |
|||
| Carcinogenicity | 0.66 (Inactive) |
|||
| Mutagenicity | 0.87 (Inactive) |
|||
| 5 (Cembrene-A) |
890 | 4 | Hepatotoxicity | 0.87 (Inactive) |
| Immunotoxicity | 0.99 (Active) |
|||
| Carcinogenicity | 0.60 (Inactive) |
|||
| Mutagenicity | 0.98 (Inactive) |
|||
| 6 (Pregnadienes) |
2300 | 5 | Hepatotoxicity | 0.67 (Inactive) |
| Immunotoxicity | 0.98 (Active) |
|||
| Carcinogenicity | 0.56 (Active) |
|||
| Mutagenicity | 0.99 (Inactive) |
|||
| 7 (Z,4Z-Furanodien-6-one) |
116 | 3 | Hepatotoxicity | 0.71 (Inactive) |
| Immunotoxicity | 0.96 (Inactive) |
|||
| Carcinogenicity | 0.58 (Inactive) |
|||
| Mutagenicity | 0.84 (Inactive) |
|||
| 8 (Guggulsterols) |
5010 | 6 | Hepatotoxicity | 0.82 (Inactive) |
| Immunotoxicity | 0.98 (Active) |
|||
| Carcinogenicity | 0.66 (Active) |
|||
| Mutagenicity | 0.67 (Inactive) |
|||
| 9 (3,4-Seco-mansumbinoic acid) |
11,800 | 2 | Hepatotoxicity | 0.51 (Active) |
| Immunotoxicity | 0.93 (Inactive) |
|||
| Carcinogenicity | 0.67 (Inactive) |
|||
| Mutagenicity | 0.88 (Inactive) |
|||