Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 17;14(8):1712. doi: 10.3390/pharmaceutics14081712

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Proposed anticancer mechanism for Bis-PMSs 5 and 6. Decreased activity of IL-6R via IL-6Rβ (gp130) targeting may cause lower levels of activated/phosphorylated STAT3. The decrease in STAT3 activity reduces expression of survival factors and mitochondrial functionality. As a result, cell proliferation is repressed and the mitochondrial apoptotic pathway is activated, respectively. Simultaneously, direct inhibition of mitochondrial metabolism by Bis-PMSs 5 and 6 leads to decreased cell growth and cell death.