Relationship of PCO2 to [HCO3–] at specific pH. Isopleths for pH 7.1 (), 7.4 (), and 7.7 () are plotted as functions of paired [HCO3–] and PCO2. Each isopleth slope equals the ratio of PCO2 to [HCO3–] (RpH). As pH varies in 0.3 increments, [H+] doubles or halves in concert with RpH. Accordingly, the respective slopes of RpH are 0.833, 1.67, and 3.33 at pH units of 7.7, 7.4, and 7.1. Corresponding, [H+] is a function of RpH.