Figure 1.

The proposed role of KLF11 in kidney endothelial cells. Endothelial cells exhibit cytoplasmic and nuclear KLF11 distribution in basal conditions. Ischemia-reperfusion-induced AKI increases translocation of KLF11 to the nucleus where it acts as a transcription factor, mediating the expression of both maladaptive and protective factors. Pleiotropic IL-6 influences both maladaptive and protective pathways downstream; in ischemic AKI, however, IL-6 is generally associated with an unfavorable functional phenotype. ET-1, endothelin-1; D2, dopamine receptor 2; PPARγ, peroxisome proliferator-activated receptor gamma. Created with BioRender.com.