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. 2022 May 6;3(8):1417–1422. doi: 10.34067/KID.0002272022

Figure 1.

Figure 1.

Alterations in renal function and histology one day after renal ischemia-reperfusion injury (IRI) in Krüppel-like factor (KLF)11+/+ and KLF−/− mice. (A) KLF11−/− mice, as compared with KLF11+/+ mice, showed significantly higher levels of serum creatinine and BUN values after IRI. Values are the mean±SEM; n=5 for each sham group, and n=6 and 7 for KLF11+/+ and KLF11−/− mice subjected to IRI, respectively. For this and subsequent statistical analyses, a t test was used for parametric data, and the Mann–Whitney U test was used for nonparametric data. ***P<0.005, KLF11−/− IRI versus KLF11+/+ IRI. (B) Representative hematoxylin and eosin staining at 1 day after IRI for 22 minutes revealed increased necrosis (arrowheads), cast formation (asterisks), tubular dilatation, and glomerular congestion (arrows) in the renal cortex of KLF11−/− mice (ii and iv) when compared with KLF11+/+ mice (i and iii). (C) The renal medulla of KLF11−/− mice (ii) at 1 day after IRI for 22 minutes showed increased necrosis and vascular congestion compared with KLF11+/+ mice (i). Scale bar 100 μm.