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Evolovumab decreases circulating LDL by its actions on hepatocytes and enhances PCSK9 levels, reducing lipotoxic renal injury. Evolocumab decreases LDL by blocking LDL receptor (LDLR) recycling, leading to increased LDLRs on hepatocytes and decreased circulating LDL. In renal cells, evolocumab enhances the degradation of CD36 by PCSK9 while reducing LDL levels through hepatic mechanisms. Created with BioRender.com.
