Table 1. Transcriptomic study reveals increased transcription of ER stress-related genes in hyperoxic BPD rat lungs compared to normoxic controls (n = 6) at P10.
| Items | Biologic process | p-value | q-FDR Bonferroni | q-FDR B&H | q-FDR B&Y | Hit | Total genes |
|---|---|---|---|---|---|---|---|
| GO:0034976 | Response to ER stress | 1.391X10-12 | 1.678X10-8 | 7.840X10-11 | 7.820X10-10 | 118 | 313 |
| GO:0006986 | Response to unfolded protein | 1.446X10-12 | 1.744X10-8 | 8.110X10-11 | 8.090X10-10 | 83 | 194 |
| GO:0034620 | Cellular response to unfolded protein | 2.884X10-9 | 3.477X10-5 | 1.073X10-7 | 1.070X10-6 | 64 | 155 |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | 7.003X10-8 | 8.444X10-4 | 2.035X10-6 | 2.030X10-5 | 54 | 132 |
| GO:1905897 | Regulation of response to ER stress | 1.737X10-7 | 2.094X10-3 | 4.781X10-6 | 4.769X10-5 | 40 | 89 |
| GO:0140467 | Integrated stress response signaling | 6.137X10-7 | 7.400X10-3 | 1.538X10-5 | 1.535X10-4 | 18 | 28 |
| GO:0030433 | Ubiquitin-dependent ERAD pathway | 4.645X10-5 | 5.601X10-1 | 8.071X10-4 | 8.050X10-3 | 33 | 83 |
| GO:0070059 | Intrinsic apoptotic signaling pathway in response to ER stress | 1.119X10-4 | 1.000 | 1.804X10-3 | 1.799X10-2 | 28 | 69 |
ER: Endoplasmic reticulum; ERAD: Endoplasmic reticulum-associated protein degradation; UPR: unfolded protein response