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. 2022 Aug 26;8(34):eabn3106. doi: 10.1126/sciadv.abn3106

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Fig. 7. — (A) Representation of HMGA2 binding sites on SOX9 promoter. (B) qPCR analysis of HMGA2 binding to SOX9 regulatory regions; significance is compared with control antibody. (C) ChIP analysis of HMGA2 binding to the three SOX9 regulatory regions. IgG, mouse IgG (negative control). (D) Triple staining of Lin28a, HMGA2, and SOX9 by confocal immunofluorescence in CT and Lin28a(Tg) OA mice. Images show 10× magnification (scale bars, 500 μm) and 20× magnification (scale bars, 200 μm). (E) Quantification of immunofluorescence percentage of cells triple positive for Lin28a, HMGA2, and SOX9 staining. Data are means ± SEM. *P < 0.05, ***P < 0.005, and ****P < 0.001 compared with CT.