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. 2022 Aug 26;8(34):eabn3106. doi: 10.1126/sciadv.abn3106

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Fig. 8. — (A) Schematic representation of the regenerative protocol applied to Col2a1-Cre^ER (CT) and Lin28a^flox/flox/Col2a1-Cre^ER [Lin28a(Tg)] mice. OA was induced in mice at age 10 weeks, and then mice were euthanized at 4 and 8 weeks after. All mice received weekly intra-articular injection of scramble siRNA (siSCR) or siRNA against HMGA2 (siHMGA2). (B) Safranin-O staining and quantification of OA score of articular cartilage (scale bars, 100 μm). (C) Immunohistochemistry of MMP13 level and quantification of MMP13-positive cells (scale bars, 100 μm). (D) Immunohistochemistry of Ki-67 expression and quantification in mouse joints with OA (scale bars, 100 μm). (E) Osteophyte volume analyzed by microtomography in mice with OA. (F) Subchondral BV/TV analyzed by microtomography in mouse joints with OA. Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.005, and ****P < 0.001.