Figure 5.

Tsc1^GFAPCKO mice have spontaneous focal seizures during an age-limited period of neonatal development. A, A representative electrographic seizure on EEG and EMG from a P9 Tsc1^GFAPCKO mouse evolves with increasing frequency and amplitude of spikes and brief post ictal suppression. The seizure appears to start first in the left hemisphere but then spreads bilaterally, suggesting a focal-onset seizure. EMG from nuchal muscle shows a modest increase in myogenic activity. B, Mean seizure frequency is increased in P9 Tsc1^GFAPCKO and subsides by P12. ***p<0.001 % in Tsc1^GFAPCKO compared to control by two-way repeated measures ANOVA with Tukey multiple comparisons posttest; n = 11–14 mice per group.