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. 2022 Aug 26;4(10):e705–e716. doi: 10.1016/S2589-7500(22)00132-7

Figure 2.

Figure 2

Unsupervised hierarchical clustering of cytokine production genes expressed in human internal mammary arteries in the study arm 1 population

(A) Unsupervised hierarchical clustering of the list of genes relevant to inflammation annotated in the Gene Ontology (GO) terms “Cytokine Production” (GO:0001816) from the GO main domain “Biological Process” and “Cytokine Activity” (GO:005125) from the GO main domain “Molecular Function”. Hierarchical clustering was done with Ward's method and Minkowski distance, with the Minkowski distance metric, p, set to 10. (B) Enriched signalling pathways of differentially expressed genes between the two clusters of vascular inflammation identified through ConsensusPathDB. (C) Feature importance of the top 20 radiomic features comprising C19-RS and their correlation with cpm (count per million) values with key inflammatory genes in the study arm 1 population (the asterisk denotes significance, p<0·05 by the Spearman's ρ correlation coefficient). An index of the radiomic features included in the figure is presented in the appendix (p 41). The full list of the 145 genes selected is also provided in the appendix (p 32). IMA=internal mammary artery.