Percentage of AgNP dissolution in water, cRPMI, PBS 1×, ALF 1× and 0.1 M CA after 24 h of incubation. Values were extracted from the normalised UV-Vis spectra and calculated according to the formula: 100(Abst=24 h − Abst=0 h). Negative values correspond to increments in absorbance over time, which is attributed to conformational changes of the PVP on the NP surface that modify the refractive index and thickness of the coating, thereby leading to alterations of the plasmon resonance conditions40.
| % dissolution at 24 h obtained by UV-Vis | ||||||
|---|---|---|---|---|---|---|
| H2O | cRPMI | PBS | ALF | CA | ||
| 37 °C | PVP | 1.3 | 17.3 | −8.3 | 23.9 | 50.1 |
| CD | 3.5 | 15.6 | 25.0 | 74.6 | 97.0 | |
| Starch | 12.8 | 15.6 | 12.5 | 54.6 | 80.4 | |
| RT | PVP | −1.5 | 4.6 | 66.6 | 63.5 | 67.9 |
| CD | 0.2 | 9.0 | 34.7 | 46.7 | 41.5 | |
| Starch | 4.3 | 4.6 | 6.8 | 22.3 | 47.5 | |