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. 2022 Aug 12;12:978006. doi: 10.3389/fonc.2022.978006

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Copyright © 2022 Chen, Zhang, Zhou, Ye, Luo, Yang, Fang and Tang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Weighted gene coexpression network analysis (WGCNA) for the construction of an HMOX1-mediated metastasis regulatory network in LUAD. (A) A scale-free network construction (power threshold β = 6). (B) Gene dendrogram generating gene modules. (C, D) Correlation analysis between modules and pathophysiological traits. HMOX1, EMT, macrophage, and mitochondrional complex had the same high correlation module (MEbrwon). (E) Gene Ontology (GO) enrichment for the MEbrown genes. (F) The construction of protein-protein interaction (PPI) network among HMOX1, macrophage, mitochondrional complex, and EMT using the MEbrown module genes. (G) The simplified interaction network among HMOX1, macrophage, mitochondrional complex, and EMT. Solid lines indicate interactions. Dashed lines indicate missing interactions.