| Polyethylene glycol (PEG) polymerized micelles |
Improved micellar adhesion, corneal surface penetration, stability and biocompatibility |
PEPP (2% BPOSS) |
0.067 wt% |
115.5 ± 1.5 nm |
LC 28%, EE 84.4% |
1 : 3 |
Fungal keratitis C57BL/6 mice |
50
|
| MPEG-b-PAE-g-HA |
— |
84.5 nm |
LC 0.56% |
1 : 10 |
Isolated rabbit cornea |
51
|
| mPEG-b-PLGA |
— |
81.3 ± 1.3 nm |
LC 8.1 ± 0.2%, EE 80.9 ± 1.6% |
1 : 9 |
Allogenic penetrating keratoplasty (SD rats to Wistar rats) |
52
|
| PEG-b-PGMA |
— |
∼200 nm |
EE 85.02 ± 3.63%, LC 20.32 ± 0.69% |
1 : 5 |
Fungal keratitis rabbits |
54
|
| Soluplus® polymeric micelles |
Improved drug solubility, stability, corneal or scleral penetration and drug uptake in ocular cells |
Soluplus® (PVCL–PVA–PEG) |
7.6 mg L−1 in 23 °C water |
60.72 ± 1.09 nm |
EE 99.5 ± 0.52% |
1 : 18 |
Eye inflammation rabbits |
56
|
| Solutol polymeric micelles |
Excellent solubilization ability, low toxicity, can be delivered to the posterior segment of the eye as an injection |
Solutol® HS 15 |
0.40 ± 0.04 mg mL−1 in artificial tears |
12.17 ± 0.73 nm |
EE 96.12 ± 0.31% |
1 : 21 |
Eye inflammation rabbits |
63
|
| Polymeric micelles with surface modifications |
Surface modification allows micelles to be charged or targeted |
CSO-VV-SA (5 : 4) |
53.70 μg mL−1
|
∼100 nm |
EE 91.95 ± 1.86, LC 6.13 ± 0.26 |
1 : 30 |
New Zealand albino rabbits |
77
|
| SDBS–Ppy (Dex) |
1–2 mM |
∼50 nm |
EE 80.5 ± 1.19, LC 6.24 ± 0.04 |
1 : 20 (molar ratio) |
— |
80
|
| Micelle-gel platform |
Improved corneal adhesion and prolonged drug release time |
F127 |
950–1000 ppm |
62.36 ± 3 nm |
EE 90.66 ± 10% |
1 : 10 |
Porcine corneal infection injury model in vitro
|
86
|
| F68 (100 mg mL−1) |
∼1.3 mg mL−1
|
131 ± 108 nm |
NA |
1 : 5 |
Excised bovine cornea |
87
|
| Micelle-loaded platform |
Improvement of the controlled release effect and stability of micelles |
mPEG–PLA |
∼0.0012 mg mL−1
|
20.96 ± 6.050 nm |
LC 8.87%, 0.078%; EE 93.2%, 74.8% (timolol and latanoprost, respectively) |
10 : 0.1 : 100 (timolol : latanoprost : polymer) |
Rabbit model of high intraocular pressure |
92
|
