Fig. 1. Landscape of somatic mutations in 222 chronic phase CML patients at diagnosis by targeted next-generation sequencing.

Mutations were found in 53/222 patients (24%) with ASXL1 being the most commonly affected gene (n = 20). Patients and genes are displayed in columns and rows, respectively. A unique color is assigned to each mutated gene. Bisected cell represents two variants in the same gene and patient.