Fig. 1. Overall distribution of frequencies of different types of clinically significant chromosomal aberrations in MDS detected by OGM represented by chromosome involvement.

A A total of 383 of 4030 unique copy number variant (CNV) (both gains and losses) plus SV calls (with subtypes, included partial tandem duplications, all involving KMT2A on chromosome 11, inversions, intra-chromosomal and inter-chromosomal translocations), as well as copy neutral loss-of-heterozygosity (CN-LOH) calls were identified. B–D The distribution of CNVs (B), SVs (C) and CN-LOH (D) represented on the Y-axes plotted across different chromosomes (chromosome number on the X-axis).