Figure 5.

Treatment with primaquine, chloroquine, or MMV048 alone or in combination

(A) Log reduction in liver parasite burden per animal 24 days post-infection. Values are normalized to the controls of the same isolate from the same infection. Drug treatment was as follows: MMV048: 30 mg/kg days 4–7; chloroquine (CQ): 10 mg/kg days 4–6; primaquine (PQ): 30 mg/kg days 4–18. The box and whiskers plot denotes the mean, Q1 and Q3 of the values pooled for each treatment group. The number of animals in each group were as follows: {control:24, PQ:9, CQ:10, MMV048:14, PQ + MMV048:11, CQ + MMV048: 7, CQ + PQ: 26, CQ + PQ + MMV048: 12}. Horizontal dashed line denotes the limit of quantification. Log₁₀ 18S rRNA per μg of liver of animals in the control group and the triple combination group for isolates (B) VTTY143, (C) VTTY125, and (D) VYBN74. Each dot represents one animal.