Table 2.

Sleep parameters and RSWA assessments

Study outcome measures: sleep variables				p value
	Baseline	5-HTP	Placebo	Baseline vs 5-HTP vs Placebo	Baseline vs 5-HTP	5-HTP vs Placebo
TST	378.1±84.3	346±76.2	323.5±85.3	.03*	ns	ns
SE	72.8±16.7	70.1±12.2	72±18.7	ns	ns	ns
WASO	109.8±73.7	84.1±58.3	98.9±83	ns	ns	ns
Arousal Index (n/h)	6.6±8.5	5.4±3.2	6.7±3.7	ns	ns	ns
N1 (%)	11.4±7	9.4±5	11.7±11.3	ns	ns	ns
N2 (%)	48.8±11.8	54.3±12.3	52±8.1	ns	ns	ns
N3 (%)	29.3±12.3	22.9±9.5	25±8	ns	.04  ^	ns
REM (%)	10.4±6.8	13.4±9.2	11.3±6.4	ns	ns	ns
REM sleep periods (n)	2.8±1.2	2.5±0.7	2.4±1.2	ns	ns	ns
% Any Chin	64.0±29.0	80.3±20.2	74.4±22.8	ns	ns	ns
%Any Chin + FDS (3 sec)	68.2±26.8	81.5±18.8	77.2±20.4	ns	ns	ns
% Any Chin + FDS (30 sec)	73.2±32.8	87.3±15.9	88.4±15.5	ns	ns	ns

Data are presented as mean and standard deviation (S.D). Abbreviations: Any, phasic and/or tonic; EMG, electromyographic; FDS, flexor digitorum superficialis; TST, Total sleep time; SE, Sleep efficiency; WASO, Wake time after sleep onset; ns, not significant; *Repeated measures one-way ANOVA;  ^ Paired t-test