Fig. 1.

An overview of the framework used in this work. Multi-modal metrics computed from the diffusion tensor (FA, MD, PSMD, RESIDUALS), T1-weighted imaging (CTH) and FLAIR (WMH) are derived at (i) the whole brain level and ii) for each major white matter tracts of the 73 obtained with an automatic tractography clustering method. The considered measures are used as input to a linear multivariate prediction model and an artificial neural network (ANN) with leave-one-out cross-validation