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Construction and working mechanism of the DNA nanodevice based vaccine. (A) Preparation of the DNA nanodevice vaccine constructed by M13mp18 DNA, tumor antigen peptide, dsRNA, CpG loops, and locking strands. (B) Schematic illustration of the lymph node targeting, acidic microenvironment responsive antigen release, and specific immune activation of the DNA nanodevice vaccine. Reproduced with permission from Ref. [127].
