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. 2022 Aug 26;12:14616. doi: 10.1038/s41598-022-19016-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proximal left tibial trabecular architecture (mean ± SD, n = 20/group). Diet had a significant main effect on every measured property except tissue mineral density (TMD), increasing trabecular bone volume (BV), bone volume/total volume (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th) and decreasing trabecular separation (Tb.Sp). For mice fed the control diet, both speeds of exercise prevented a significant decrease in BV/TV from baseline. #Significant diet effect (p < 0.05, Two-way ANOVA). *Significant exercise effect (p < 0.05, Two-way ANOVA). ^Significantly different from baseline (p < 0.05, Tukey’s test). Horizontal bar represents significant difference between groups (p < 0.05, Tukey’s test).