Table 2.
Overall and disease-specific mortality in subjects with analysed intestinal disorders.
| Cause of death | Coeliac disease [K90] (n = 3001) | Ulcerative colitis [K51] (n = 4399) | Crohn’s disease [K50] (n = 2020) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | deaths/1000 PYs | HR | 95%-CI | n | deaths/1000 PYs | HR | 95%-CI | n | deaths/1000 PYs | HR | 95%-CI | |
| Overall mortality | 271 | 7.72 | 1.38 | 1.22–1.55 | 437 | 8.49 | 1.32 | 1.20–1.46 | 250 | 10.67 | 1.91 | 1.70–2.17 |
| Malignancies (C00-C97) | 129 | 3.67 | 1.22 | 1.03–1.45 | 205 | 3.98 | 1.25 | 1.09–1.43 | 108 | 4.61 | 1.60 | 1.33–1.93 |
| Digestive diseases (K00-K93) | 17 | 0.48 | 2.58 | 1.60–4.16 | 37 | 0.72 | 3.14 | 2.26–4.35 | 30 | 1.28 | 6.45 | 4.49–9.26 |
| Cardiovascular diseases (I00-I99) | 51 | 1.45 | 1.41 | 1.07–1.86 | 88 | 1.71 | 1.21 | 0.98–1.50 | 50 | 2.13 | 1.90 | 1.44–2.52 |
| Respiratory diseases (J00-J99) | 25 | 0.71 | 1.76 | 1.18–2.61 | 32 | 0.62 | 1.32 | 0.93–1.88 | 21 | 0.90 | 2.29 | 1.49–3.52 |
Multivariable hazard ratios were determined for patients with coeliac disease, ulcerative colitis, and Crohn’s disease compared to the reference group that displays none of these conditions.
All analyses were adjusted for age, sex and body mass index.
For details, see Supplementary Table S4.
PYs person-years, CI confidence interval, HR hazard ratio.
Significant values are in bold.