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. 2022 Aug 26;13(8):737. doi: 10.1038/s41419-022-05168-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Representative data graphic of oxygen consumption rate (OCR) obtained from the Cell Mito Stress Test. Mitochondrial respiration expressed as normalized OCR of control, HGPS and HGPS TM5441-treated cells after the sequential addition of oligomycin, FCCP, rotenone and antimycin as indicated. B The basal respiration which represents the oxygen consumption used to meet cellular ATP demand in resting condition. C Mitochondrial ATP production, calculated as the OCR difference between the baseline and after the addition of oligomycin. D The maximal respiration measured as the maximal oxygen consumption rate attained by adding the uncoupler FCCP. E The spare respiratory capacity obtained from the analysis of the Maximal respiration. F The cellular energy diagram showing the normalized oxygen consumption rate (OCR) and the normalized extracellular acidification rate (ECAR) of control, HGPS and HGPS TM5441-treated cells at baseline and stressed conditions. G, H Metabolic potential of control, HGPS and HGPS TM5441-treated fibroblasts was calculated from unstressed G and stressed (H) OCR/ECAR over baseline.