Figure 6.
Biological validation of the angiogenesis modeling. (a) Our simulations show that the branching of new vessels occurs near the tumor boundary and inside the tumor; in vivo observations of tumor angiogenesis by (b) Vakoc et al.53 and (c) Roudnicky et al.54. (d) The sprouting angiogenesis induced by one parent vessel form vascular loops; and in vivo observations of tumor angiogenesis by (e) Vakoc et al.53 and (f) Roudnicky et al.54. It should be mentioned that (b) and (e) are extracted from Vakoc et al.53 with permissions. Additionally, (c) and (f) are taken from Roudnicky et al.54 with permissions.