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Conformational heterogeneity in GPCR–GRK1 interactions. Superposition of the Rho–GRK1 structure in the presence of Fab1 (PDB entry 7MTA) or Fab6 (PDB entry 7MTB) (52) with either (A) receptor or (B) GRK1 aligned. GPCR, G protein-coupled receptor; GRK, G protein-coupled receptor kinase; H8, helix 8; Rho, rhodopsin; TM, transmembrane.
