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. 2022 Jul 19;298(9):102279. doi: 10.1016/j.jbc.2022.102279

Figure 6.

Figure 6

Comparison of GPCRs bound to G proteins, GRK1, and arrestins show subtle differences but somewhat more condensed cytoplasmic clefts.A, overlay of G protein mimic nanobody (NB80) (PDB entry 6IBL) (36), Gs (PDB entry 7JJO) (73), and Arr2 (PDB entry 6TKO) (36) bound to the β1AR. B, overlay of Gi (PDB entry 6OSA and 6OS9) (78) and Arr2 (PDB entries 6PWC and 6UP7) (33, 34) bound to NTSR1. C, overlay of Go (PDB entry 6OIK) (79) and Arr2 (PDB entry 6U1N) (35) bound to the Μ2R. D, overlay of GRK1 (PDB entry 7TMA) (52), Gt (PDB entry 6OYA) (71), and Arr1 (PDB entry 5W0P) (18) bound to Rho. β1AR, β1 adrenergic receptor; Arr1, arrestin-1; Arr2, arrestin-2; GPCR, G protein-coupled receptor; GRK, G protein-coupled receptor kinase; H8, helix 8; ICL, intracelluar loop; NTSR1, neurotensin receptor 1; Rho, rhodopsin; TM, transmembrane.