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5-LOX reaction with arachidonic acid. (top) 5-LOX adds molecular oxygen to AA at the C5 after hydrogen abstraction at C7. (middle) The generation of 5(S)-hydroperoxyeicosatetraenoic acid (5-HPETE) can be monitored by UV/Vis at 235 nm. (bottom) 5-LOX can perform a second reaction, the dehydration of 5-HPETE to allylic epoxide leukotriene A4, which absorbs at 270 nm. 5-LOX, 5-lipoxygenase.
