Fig. 3.

Genetic ablation of CXCR2 ameliorates Ang II-induced retinopathy in mice.

(A) WT C57BL/6J mice and CXCR2 KO mice were both infused with angiotensin II or saline for three weeks. H&E-stained central retina sections (left). Retinal thickness was quantified (right, n = 8–10). (B) Representative angiograms and fundus photographs of retinal vessels (left); the arrows indicate leakage of fluorescein perivascularly and the corresponding fundus photograph area. The arteriovenous ratio and quantification of fluorescence intensity (right, n = 6). (C) DHE red fluorescence staining for analysis of superoxide production in the retinas of each group (left) and intensity quantification (right, n = 6). (D) Typical waveforms of oscillatory potentials and their amplitude quantification (n = 6). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)