Figure 1.

Overview and taxonomic microbiota composition of the FMT meta-cohort

(A) Overview of treatment modalities, number and distribution of cases, and samples for 13 studies (Table S1) from five conditions included in the FMT meta-cohort.

(B) Taxonomic microbiota compositions based on principal-component analysis (PCA) of centered log-ratio-transformed relative species abundance. Samples in the main plot are categorized and color-coded as pre-FMT^ABx− (blue), antibiotically pretreated pre-FMT^ABx+ (purple), and post-FMT (yellow) patient and donor (red) samples. Ridgeline density plots show sample distributions along the two first principal components based on the same categories. In the small plots (right side) samples from the same PCA are color-coded based on (from top to bottom) scaled cumulative relative abundances of Bacteroidetes, Firmicutes, dysbiosis score,²³ and ɑ-diversity (Shannon index).

(C) Ridgeline density plots showing only pre-FMT (untreated and antibiotically pretreated) patient samples, colored by disease category. The MDR studies included patients with a history of antibiotic treatments, even before the beginning of the FMT trials.