Table 1.
Demographic Characteristics of Study Participants
| Demographic | Part 1 (SAD) N = 24 | Part 2 (MAD) N = 16 | Part 3 (BA) N = 8 |
|---|---|---|---|
| Age (years) | |||
| Mean (SD) | 49.4 (8.07) | 67.9 (5.47) | 37.8 (7.25) |
| Median | 49.5 | 67.0 | 39.0 |
| Min, Max | 27, 60 | 62, 79 | 24, 48 |
| Sex (n [%]) | |||
| Male | 11 (45.8%) | 6 (37.5%) | 6 (75.0%) |
| Female | 13 (54.2%) | 10 (62.5%) | 2 (25.0%) |
| Ethnicity (n [%]) | |||
| Hispanic or Latino | 17 (70.8%) | 10 (62.5%) | 5 (62.5%) |
| Not Hispanic or Latino | 7 (29.2%) | 6 (37.5%) | 3 (37.5%) |
| Race | |||
| Asian | 1 (4.2%) | 0 | 0 |
| Black or African American | 4 (16.7%) | 1 (6.3%) | 2 (25.0%) |
| White | 16 (79.2%) | 14 (87.5%) | 6 (75.0%) |
| Other | 0 | 1 (6.3%) | 0 |
| Weight (kg) | |||
| Mean (SD) | 76.48 (11.49) | 72.38 (11.27) | 79.80 (18.91) |
| Median | 76.40 | 70.35 | 70.75 |
| Min, Max | 57.5, 101.2 | 53.2, 91.2 | 60.9, 118.7 |
| Height (cm) | |||
| Mean (SD) | 165.40 (10.85) | 163.48 (11.04) | 171.61 (11.64) |
| Median | 164.65 | 158.95 | 171.45 |
| Min, Max | 151.5, 191.1 | 148.0, 188.2 | 158.0, 195.0 |
| Body Mass Index (kg/m2) | |||
| Mean (SD) | 27.85 (2.27) | 27.04 (3.03) | 26.79 (3.34) |
| Median | 27.35 | 27.35 | 26.40 |
| Min, Max | 23.9, 32.0 | 20.9, 31.1 | 22.9, 31.2 |
Abbreviations: MAD = multiple ascending dose; Max = maximum; Min = minimum; N = total number of subjects; SAD = single ascending dose; SD = standard deviation;
Note: Percentages are calculated as 100 ⋆ (number of subjects [n]/N).